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KMID : 0380620080400050599
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 5 p.599 ~ p.602
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Analysis of Vicamine Using High Performance Liquid Chromatography and Antioxidant Activity of Vincaminor Extract
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Jung Jong-Hee
Baek Yu-Mi
Lee Kwang-Geun
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Abstract
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Vincamine, one of the major indole alkaloids in vincaminor (Vinca minor L.) is commonly used for treating cerebrovascular diseases. The antioxidant activity of vincaminor extracts and vincamine were measured by 1.1-diphenyl-2-picrylhydrazyl (DPPH) and lipid malonaldehyde (MA) assay. Vincaminor leaves were pulverized and extracted with various solvents such as water, methanol, and ethanol. The antioxidant activities of the extracts varied in accordance with solvents and assays. In DPPH assay, the water extract showed the highest antioxidant activity. In lipid MA assay, However, the ethanol extract inhibited MA formation from cod liver oil by 82% at the level of 5,000 μg/mL. Vincamine in the extract was analyzed by high-performance liquid chromatogram and the concentration of vincamine was 0.419±0.005 μg/mL.
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KEYWORD
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vincamine, vincaminor, antioxidant activity, lipid malonaldehyde, high perpormance liquid chromatography
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